An internal standard for the quantification of indoramin
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Indoramin-d5

Item No. 45855

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl]-benzamide-2,3,4,5,6-d5
CAS Number
57165-41-0
Molecular Formula
C22H20D5N3O
Formula Weight
352.5
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A 1 mg/ml solution in methanol
SMILES
O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])NC(CC2)CCN2CCC3=CNC4=CC=CC=C34
InChi Code
InChI=1S/C22H25N3O/c26-22(17-6-2-1-3-7-17)24-19-11-14-25(15-12-19)13-10-18-16-23-21-9-5-4-8-20(18)21/h1-9,16,19,23H,10-15H2,(H,24,26)/i1D,2D,3D,6D,7D
InChi Key
JXZZEXZZKAWDSP-FSTBWYLISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $64

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    5 mg

    $304

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    Product Description

    Indoramin-d5 is intended for use as an internal standard for the quantification of indoramin by GC- or LC-MS. Indoramin is an antagonist of α1-adrenergic receptors (α1-ARs; Kis = 5, 10, and 50 nM for the human α1A-, α1B-, and α1D-ARs, respectively).1 It also binds to α1L-ARs (pA2 = 8.5) and inhibits norepinephrine and serotonin (5-HT) uptake in rat brain cortical slices (IC50 = 2 µM for both).2,3 Indoramin (5 mg/kg) decreases blood pressure in normotensive anesthetized rats.4 Intrathecal administration of indoramin decreases micturition pressure and increases bladder capacity and micturition volume in conscious rats.5 Formulations containing indoramin have been used in the treatment of urinary outflow obstruction in patients with benign prostatic hyperplasia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al. Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studies. Br. J. Pharmacol. 118(4), 871-878 (1996).

    2. Ford, A.P.D.W., Arrendondo, N.F., Blue, D.R., Jr., et al. RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α, α-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in human prostate: Implications for adrenoceptor classification. Mol. Pharmacol. 49(2), 209-215 (1996).

    3. Sugden, R.F. The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices. Br. J. Pharmacol. 51(3), 467-469 (1974).

    4. Archibald, J.L., Alps, B.J., Cavalla, J.F., et al. Synthesis and hypotensive activity of benzamidopiperidylethylindoles. J. Med. Chem. 14(11), 1054-1059 (1971).

    5. Ishizuka, O., Pandita, R.K., Mattiasson, A., et al. Stimulation of bladder activity by volume, L-dopa and capsaicin in normal conscious rats - effects of spinal α1-adrenoceptor blockade. Naunyn Schmiedebergs Arch. Pharmacol. 355(6), 787-793 (1997).