An active metabolite of acetaminophen
Related Products
Parent Compound(s)
10024Acetaminophen
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3-Hydroxyacetaminophen

Item No. 45936

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3,4-dihydroxyphenyl)-acetamide
CAS Number
37519-14-5
Synonyms
  • 3-hydroxy APAP
  • 3’-Hydroxyacetanilide
Molecular Formula
C8H9NO3
Formula Weight
167.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C)NC1=CC=C(C(O)=C1)O
InChi Code
InChI=1S/C8H9NO3/c1-5(10)9-6-2-3-7(11)8(12)4-6/h2-4,11-12H,1H3,(H,9,10)
InChi Key
IPFBMHOMTSBTSU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $60

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    500 mg

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    1 g

    $216

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    Product Description

    3-Hydroxyacetaminophen is an active metabolite of acetaminophen (Item No. 10024).1 It is formed from acetaminophen by the cytochrome P450 (CYP) isoforms CYP2C11, -2A1, -2C12, -2B1, -3A, and -1A, among others. 3-Hydroxyacetaminophen induces hepatic necrosis to a lesser extent than acetaminophen in mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harvison, P.J., Guengerich, F.P., Rashed, M.S., et al. Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen. Chem. Res. Toxicol. 1(1), 47-52 (1998).

    2. Forte, A.J., Wilson, J.M., Slattery, J.T., et al. The formation and toxicity of catechol metabolites of acetaminophen in mice. Drug. Metab. Dispos. 12(4), 484-491 (1984).