An inducer of autophagy
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

THPN

Item No. 45944

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(3,4,5-trihydroxyphenyl)-1-nonanone
CAS Number
100079-26-3
Molecular Formula
C15H22O4
Formula Weight
266.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O
InChi Code
InChI=1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3
InChi Key
NVFRHTFJDGAFQS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $29

    Add

    5 mg

    $116

    Add

    10 mg

    $218

    Add

    25 mg

    $435

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    THPN is an inducer of autophagy and a derivative of gallic acid (Item No. 11846).1 It binds to the ligand-binding domain (LBD) of Nur77 (Kd = 0.27 µM), which increases NIP3L-facilitated translocation of Nur77 to the mitochondria and induces autophagy in A375 melanoma cells. THPN reduces viability of L1210 and CEM leukemia cells (IC50s = 22 and 50 µM, respectively).2 It also reduces cytoplasmic and mitochondrial glutathione levels and increases NF-κB levels in L1210 cells. THPN (20 mg/kg) inhibits the formation of tumors in the lungs and liver in a B16/F10 murine melanoma model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, W.J., Wang, Y., Chen, H.Z., et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat. Chem. Biol. 10(2), 133-140 (2014).

    2. Locatelli, C., Rosso, R., Santos-Silva, M.C., et al. Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells. Bioorg. Med. Chem. 16(7), 3791-3799 (2008).