Myricanol

Myricanol is a cyclic diarylheptanoid that has been found in M. nagi and has diverse biological activities.^1,2,3,4,5 It inhibits the type III secretion system of S. typhimurium (IC₅₀ = 41.34 µM) and the invasion of S. typhimurium into SW480 cells.¹ Myricanol binds to AMP-activated protein kinase γ (AMPKγ; K_i = 17.15 µM) and peroxiredoxin-5 (Prx5) and decreases lipid accumulation in 3T3-L1 adipocytes.^2,5 It is an activator of nicotinamide phosphoribosyltransferase (Nampt) and sirtuin 1 (SIRT1) and increases insulin-induced glucose uptake in C2C12 myotubes.^3,4 Myricanol (50 mg/kg) protects against muscle dysfunction induced by dexamethasone (Item No. 11015) in mice.⁴

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1. Wu, Y., Yang, X., Zhang, D., et al. Myricanol inhibits the type III secretion system of Salmonella enterica serovar Typhimurium by interfering with the DNA-binding activity of HilD. Front. Microbiol. 11, 571217 (2020).

2. Shen, S., Liao, Q., Feng, Y., et al. Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase. Food Chem. 270, 305-314 (2019).

3. Lyu, P., Li, S., Han, Y., et al. Affinity-based protein profiling-driven discovery of myricanol as a Nampt activator. Bioorg. Chem. 133, 106435 (2023).

4. Shen, S., Liao, Q., Liu, J., et al. Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism. J. Cachexia Sarcopenia Muscle 10(2), 429-444 (2019).

5. Shen, S., Liao, Q., Lyu, P., et al. Myricanol prevents aging-related sarcopenia by rescuing mitochondrial dysfunction via targeting peroxiredoxin 5. MedComm (2020) 5(6), e566 (2024).