A cardiolipin-mimetic ionizable cationic lipid
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Lipid PL40

Item No. 46017

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetra(undecan-3-yl) 8,8',8'',8'''-((((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanediyl))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetraoctanoate
CAS Number
3119903-62-4
Molecular Formula
C86H170O14N4P2
Formula Weight
1546.3
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCC(CC)OC(CCCCCCCOP(OCCCCCCCC(OC(CC)CCCCCCCC)=O)(NCCCN1CCN(CC1)CCCNP(OCCCCCCCC(OC(CC)CCCCCCCC)=O)(OCCCCCCCC(OC(CC)CCCCCCCC)=O)=O)=O)=O(OCCCCCCCC(OC(CCCCCCCC)CC)=O)=O)=O)CC
InChi Code
InChI=1S/C86H170N4O14P2/c1-9-17-21-25-33-45-59-79(13-5)101-83(91)63-49-37-29-41-53-75-97-105(95,98-76-54-42-30-38-50-64-84(92)102-80(14-6)60-46-34-26-22-18-10-2)87-67-57-69-89-71-73-90(74-72-89)70-58-68-88-106(96,99-77-55-43-31-39-51-65-85(93)103-81(15-7)61-47-35-27-23-19-11-3)100-78-56-44-32-40-52-66-86(94)104-82(16-8)62-48-36-28-24-20-12-4/h79-82H,9-78H2,1-8H3,(H,87,95)(H,88,96)
InChi Key
FPHMRDQQYQFBDX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $78

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    5 mg

    $351

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    10 mg

    $624

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    Product Description

    Lipid PL40 is a cardiolipin-mimetic ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) to deliver mRNA and circular RNA (circRNA) in vitro and in vivo.1 LNPs containing lipid PL40 exhibit a ~2-fold increase in cellular uptake in primary T cells compared to LNPs containing ALC-0315 (Item No. 34337). Lipid PL40-containing LNPs encapsulating mouse chimeric antigen receptor mRNA targeting mouse urokinase-type plasminogen activator receptor (mCAR-uPAR) reduce liver damage and fibrotic scarring in a mouse model of liver fibrosis induced by carbon tetrachloride (CCl4). Lipid PL40-containing, mCAR-uPAR-encapsulating LNPs also reduce symptom severity and hind paw thickness and increase T cell-mediated clearance of senescent cells in the joints in a mouse model of collagen-induced arthritis (CIA).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Z., Ma, B., Li, B., et al. Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging. Cell Rep. Med. 6(7), 102209 (2025).