A non-phthalate plasticizer
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Tris(2-ethylhexyl)trimellitate

Item No. 46059

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,4-benzenetricarboxylic acid, 1,2,4-tris(2-ethylhexyl) ester
CAS Number
3319-31-1
Synonyms
  • TOTM
  • Trioctyl Trimellitate
Molecular Formula
C33H54O6
Formula Weight
546.8
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(C1=CC=C(C(C(OCC(CCCC)CC)=O)=C1)C(OCC(CCCC)CC)=O)OCC(CCCC)CC
InChi Code
InChI=1S/C33H54O6/c1-7-13-16-25(10-4)22-37-31(34)28-19-20-29(32(35)38-23-26(11-5)17-14-8-2)30(21-28)33(36)39-24-27(12-6)18-15-9-3/h19-21,25-27H,7-18,22-24H2,1-6H3
InChi Key
KRADHMIOFJQKEZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Tris(2-ethylhexyl)-trimellitate (TOTM) is a non-phthalate plasticizer.1 It reduces the survival rate in zebrafish (D. rerio), with a lowest observed effect concentration (LOEC) of 43.7 µg/L, but not in Japanese medaka (O. latipes) at concentrations up to 5,016.5 µg/L. Oral administration of TOTM (300 and 1,000 mg/kg per day) decreases the number of spermatocytes and spermatids in male rats but does not affect body weight, food consumption, or reproductive organ weight in male or female rats.2 It induces hepatic injury in mice, increasing serum aspartate aminotransferase (AST), alanine transaminase (ALT), TNF-α, IL-1β, and IL-6 levels and induces hepatic lipid droplet formation and inflammatory cell infiltration.3 TOTM has been found in soil, freshwater, and seawater.4,5 Formulations containing TOTM have been used as plasticizers, including in polyvinyl chloride (PVC) plastics, cables, and medical devices.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsuo, Y., Jiang, J.J., and Horie, Y. Comprehensive assessment of tris(2-ethylhexyl) trimellitate acute toxicity and ecological risks: Species-specific sensitivity and environmental monitoring. Environ. Pollut. 377, 126413 (2025).

    2. Den Braver-Sewradj, S.P., Piersma, A., and Hessel, E.V.S. An update on the hazard of and exposure to diethyl hexyl phthalate (DEHP) alternatives used in medical devices. Crit. Rev. Toxicol. 50(8), 650-672 (2020).

    3. Chen, X.H., Ma, L., Hu, Y.X., et al. Transcriptome profiling and pathway analysis of hepatotoxicity induced by tris (2-ethylhexyl) trimellitate (TOTM) in mice. Environ. Toxicol. Pharmacol. 41, 62-71 (2016).

    4. Billings, A., Carter, H., Cross, R.K., et al. Co-occurrence of macroplastics, microplastics, and legacy and emerging plasticisers in UK soils. Sci. Total Environ. 880, 163258 (2023).

    5. Horie, Y., Matsuo, Y., Yamaji, K., et al. Emerging plasticizer pollution in Thailand: Occurrence, distribution, and ecological risks of phthalate and non-phthalate esters. Mar. Pollut. Bull. 229, 119721 (2026).