A metabolite of xylene
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Isomer(s)
343762-Methylhippuric Acid
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4-Methylhippuric Acid

Item No. 46067

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-methylbenzoyl)-glycine
CAS Number
27115-50-0
Synonyms
  • para-Methylhippuric Acid
  • p-Methylhippuric Acid
  • 4-MHA
  • NSC 126814
  • p-Toluric Acid
Molecular Formula
C10H11NO3
Formula Weight
193.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
CC1=CC=C(C(NCC(O)=O)=O)C=C1
InChi Code
InChI=1S/C10H11NO3/c1-7-2-4-8(5-3-7)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)(H,12,13)
InChi Key
NRSCPTLHWVWLLH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-Methylhippuric acid (4-MHA) is a metabolite of the volatile organic compound (VOC) and organic solvent xylene.1 It has been used as a urinary biomarker for xylene exposure.2 Higher urinary levels of 3- and 4-MHA are associated with an increased risk of high-frequency hearing loss and of osteoporosis.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Szúcs, S., Tóth, L., Legoza, J., et al. Simultaneous determination of styrene, toluene, and xylene metabolites in urine by gas chromatography/mass spectrometry. Arch. Toxicol. 76(10), 560-569 (2002).

    2. da Deus Honório, T.C., de Oliveira Neto, J.R., Oliveira, F.N.M., et al. Occupational exposure evaluation of Brazil university community to the volatile organic compounds. J. Pharm. Biomed. Anal. 191, 113637 (2020).

    3. Liu, Y., Long, Z., Qiu, J., et al. Combined effects of benzene, toluene, xylene, ethylbenzene, and styrene exposure on hearing loss mediated by oxidative stress at realistic low levels. Environ. Pollut. 363(Pt 1), 125149 (2024).

    4. Zhou, H., Cui, Z., Di, D., et al. Connecting volatile organic compounds exposure to osteoporosis risk via oxidative stress based on adverse outcome pathway methodology. J. Environ. Sci. (China) 155, 806-817 (2025).