An active metabolite of imidacloprid
Related Products
Parent Compound(s)
24130Imidacloprid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Desnitro-imidacloprid

Item No. 46092

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(6-chloro-3-pyridinyl)methyl]-4,5-dihydro-1H-imidazol-2-amine
CAS Number
115970-17-7
Synonyms
  • DNIMI
Molecular Formula
C9H11ClN4
Formula Weight
210.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=NC=C(CN2C(N)=NCC2)C=C1
InChi Code
InChI=1S/C9H11ClN4/c10-8-2-1-7(5-13-8)6-14-4-3-12-9(14)11/h1-2,5H,3-4,6H2,(H2,11,12)
InChi Key
UEQZFAGVRGWPDK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $34

    Add

    5 mg

    $153

    Add

    10 mg

    $272

    Add

    25 mg

    $595

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Desnitro-imidacloprid (DNIMI) is an active metabolite of the neonicotinoid insecticide imidacloprid (Item No. 24130).1 It selectively binds to mammalian α1γα1δβ1-, α3β2β4α5-, α4β2-, and α7 nicotinic acetylcholine receptors (nAChRs; IC50s = 11, 9.9, 14, and 8.2 nM, respectively) over D. melanogaster nAChRs (IC50 = 1,530 nM). Unlike imidacloprid, DNIMI is not toxic to D. melanogaster (LD50 = >5 µg/g) but is toxic to mice (LD50 = 6-9 mg/kg). DNIMI (200 µg/ml) decreases the growth of, induces rupture of, and reduces progesterone, testosterone, and estradiol levels in, isolated mouse antral follicles.2 It has been found in human urine and drinking water.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tomizawa, M., Lee, D.L., and Casida, J.E. Neonicotinoid insecticides: Molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J. Agric. Food Chem. 48(12), 6016-6024 (2000).

    2. Mourikes, V.E., Santacruz Márquez, R., Deviney, A., et al. Imidacloprid and its bioactive metabolite, desnitro-imidacloprid, differentially affect ovarian antral follicle growth, morphology, and hormone synthesis in vitro. Toxics 11(4), 349 (2023).

    3. Wang, A., Mahai, G., Wan, Y., et al. Assessment of imidacloprid related exposure using imidacloprid-olefin and desnitro-imidacloprid: Neonicotinoid insecticides in human urine in Wuhan, China. Environ. Int. 141, 105785 (2020).

    4. Wan, Y., Han, Q., Wang, Y., et al. Five degradates of imidacloprid in source water, treated water, and tap water in Wuhan, central China. Sci. Total Environ. 741, 140227 (2020).