Host: HEK293 cells • AA: 22-124 • MW: ~11 kDa (monomer); ~53 kDa (pentamer)
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Unmodified Version(s)
46349Cholera Toxin B Subunit (recombinant)
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Cholera Toxin B Subunit (recombinant) - Biotinylated

Item No. 46159

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cholera Enterotoxin B Chain
  • Cholera Enterotoxin Subunit B
  • Choleragenoid
  • CTB
  • CTxB
Source
Recombinant CTB expressed in HEK293 cells
Amino Acids
22-124
MW
~11 kDa (monomer); ~53 kDa (pentamer)
Formulation (Request formulation change)
1 mg/ml after resuspension in 100 µl of desired buffer
UniProt Accession №
P01556
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 µg

    $440

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    Product Description

    Cholera Toxin B Subunit (recombinant) - Biotinylated is a biotinylated form of cholera toxin B subunit, a multimeric protein produced by V. cholerae.1,2 The non-toxic pentameric B subunit of cholera toxin binds to ganglioside GM1 (Item No. 19579), which acts as a receptor on mammalian cells, and facilitates entry of the toxic A subunit into cells.3,1 Biotinylated cholera toxin B subunit has been used in glycosphingolipid and membrane biology as a probe for ganglioside GM1 in the study of lipid rafts.4,5 It has also been used for transneuronal tracing due to its ability to be transferred between neurons.6 Cayman’s Cholera Toxin B Subunit (recombinant) - Biotinylated protein can be used in cell culture and for ELISA and GM1 binding assay applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cho, J.A., Chinnapen, D.J.F., Amar, E., et al. Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front. Cell. Infect. Microbiol. 2(51), (2012).

    2. Baldauf, K.J., Royal, J.M., Hamorsky, K.T., et al. Cholera toxin B: One subunit with many pharmaceutical applications. Toxins (Basel) 7(3), 974-996 (2015).

    3. Turnbull, W.B., Precious, B.L., and Homans, S.W. Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetry. J. Am. Chem. Soc. 126(4), 1047-1054 (2004).

    4. Geng, L., Zhang, H.L., and Peng, H.B. The formation of acetylcholine receptor clusters visualized with quantum dots. BMC Neurosci. 10, 80 (2009).

    5. Gylys, K.H., Fein, J.A., Yang, F., et al. Increased cholesterol in Abeta-positive nerve terminals from Alzheimer’s disease cortex. Neurobiol. Aging 28(1), 8-17 (2007).

    6. Lai, B.-Q., Qiu, X.-C., Zhang, K., et al. Cholera toxin B subunit shows transneuronal tracing after injection in an injured sciatic nerve. PLoS One 10(12), e0144030 (2015).