A penetration enhancer
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Laurocapram

Item No. 46170

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-dodecylhexahydro-2H-azepin-2-one
CAS Number
59227-89-3
Molecular Formula
C18H35NO
Formula Weight
281.5
Purity
≥95%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
CCCCCCCCCCCCN1CCCCCC1=O
InChi Code
InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)20/h2-17H2,1H3
InChi Key
AXTGDCSMTYGJND-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $49

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    10 g

    $93

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    25 g

    $221

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    50 g

    $392

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    Cayman Chemical
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    Product Description

    Laurocapram is a penetration enhancer.1 It facilitates the absorption of lipophilic or hydrophilic molecules through the skin by increasing the fluidity of stratum corneum lipids, thereby enhancing diffusion. Laurocapram synergistically potentiates the activity of β-lactam and aminoglycoside antibiotics against methicillin-resistant S. aureus (MRSA) in vitro.2 When applied topically with cefixime (Item No. 17176), the penetration-enhancing properties of laurocapram enable cefixime-mediated anti-inflammatory, antibacterial, and wound repair effects in a mouse model of MRSA-induced skin infection and anti-inflammatory and antibacterial effects in a mouse model of MRSA-induced pneumonia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. López-Cervantes, M., Márquez-Mejía, E., Cázares-Delgadillo, J., et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives. Drug Dev. Ind. Pharm. 32(3), 267-286 (2006).

    2. Wang, N., Li, W., Yu, H., et al. Laurocapram, a transdermal enhancer, boosts cephalosporin’s antibacterial activity against methicillin-resistant Staphylococcus aureus. Biochem. Pharmacol. 227:116404, (2024).