A cephalosporin antibiotic
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Cefixime

Item No. 17176

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
79350-37-1
Synonyms
  • CL-284635
  • FK-027
  • FR17027
Molecular Formula
C16H15N5O7S2
Formula Weight
453.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
205, 232, 295 nm
SMILES
[H][C@@]1([C@@H]2NC(/C(C3=CSC(N)=N3)=N\OCC(O)=O)=O)N(C(C(O)=O)=C(C=C)CS1)C2=O
InChi Code
InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
InChi Key
OKBVVJOGVLARMR-QSWIMTSFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Cefixime is a cephalosporin antibiotic.1 It is active against numerous Gram-negative bacteria, including clinical isolates of E. coli, K. pneumoniae, and P. mirabilis (MIC90s = 3.13, 0.2, and ≤0.025 µg/ml, respectively), as well as clinical isolates of the Gram-positive bacteria S. pneumoniae and S. pyogenes (MIC90s = 0.2 and 0.39 µg/ml, respectively).2 Cefixime is resistant to hydrolysis by β-lactamases isolated from several bacteria compared to cefaclor (Item No. 23626), cephalexin (Item No. 9002009), or cefradine (Item No. 26060).1 It increases survival in mice infected with E. coli, K. pneumoniae, or P. mirabilis (ED50s = 0.212, 0.132, and 0.349 mg/kg, respectively).2 Formulations containing cefixime have been used in the treatment of bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Neu, H.C., Chin, N.X., and Labthavikul, P. Comparative in vitro activity and β-lactamase stability of FR 17027, a new orally active cephalosporin. Antimicrob. Agents Chemother. 26(2), 174-180 (1984).

    2. Kamimura, T., Kojo, H., Matsumoto, Y., et al. In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic. Antimicrob. Agents Chemother. 25(1), 98-104 (1984).