Isofraxidin

Isofraxidin is a coumarin that has been found in A. senticosus and has diverse biological activities.^1,2,3,4,5,6 It induces apoptosis in, and inhibits the migration and invasion of, A549 lung cancer cells at 10 µM.² Isofraxidin decreases IL-1β-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂; Item No. 14010) production in primary chondrocytes isolated from patients with osteoarthritis.³ It reduces infarct size in a mouse model of myocardial infarction and decreases motor impairments in a mouse model of Parkinson’s disease.^4,5 Isofraxidin (3-30 mg/kg) reverses stress-induced decreases in body weight gain and increases in immobility time in the forced swim test in mice.⁶ It also has antioxidant, antimalarial, and pain-reducing activities, among others.¹

WARNING This product is not for human or veterinary use.

1. Majnooni, M.B., Fakhri, S., Shokoohinia, Y., et al. Isofraxidin: Synthesis, biosynthesis, isolation, pharmacokinetic and pharmacological properties. Molecules 25(9), 2040 (2020).

2. Zhang, H., Feng, Q.-Q., Gong, J.-H., et al. Anticancer effects of isofraxidin against A549 human lung cancer cells via the EGFR signaling pathway. Mol. Med. Rep. 18(1), 407-414 (2018).

3. Lin, J., Li, X., Qi, W., et al. Isofraxidin inhibits interleukin-1β induced inflammatory response in human osteoarthritis chondrocytes. Int. Immunopharmacol. 64, 238-245 (2018).

4. Chen, G., Song, X., Lin, D., et al. Isofraxidin alleviates myocardial infarction through NLRP3 inflammasome inhibition. Inflammation 43(2), 712-721 (2020).

5. Wang, T.-A., Li, S.-Y., Fann, L.-Y., et al. Neuroprotective potential of isofraxidin: Alleviating parkinsonian symptoms, inflammation and microglial activation. J. Cent. Nerv. Syst. Dis. 17, 1-13 (2025).

6. Wu, X., Gu, J., Zou, Z., et al. Suppressive effects of isofraxidin on depressive-like behaviors induced by chronic unpredictable mild stress in mice. Brain Sci. 12(10), 1376 (2022).