A coumarin derivative with diverse biological activities
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Cytogenin

Item No. 40220

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-hydroxy-3-(hydroxymethyl)-6-methoxy-1H-2-benzopyran-1-one
CAS Number
132971-59-6
Molecular Formula
C11H10O5
Formula Weight
222.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1OC(CO)=CC2=C1C(O)=CC(OC)=C2
InChi Code
InChI=1S/C11H10O5/c1-15-7-2-6-3-8(5-12)16-11(14)10(6)9(13)4-7/h2-4,12-13H,5H2,1H3
InChi Key
CAWNOJXNAUEIGB-UHFFFAOYSA-N
Origin
Bacterium/Streptoverticillium eurocidicum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $468

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    Cayman Chemical
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    Product Description

    Cytogenin is a coumarin derivative originally found in S. eurocidicum that has diverse biological activities.1,2 It reduces tumor weight in an Ehrlich murine spontaneous adenocarcinoma model when administered at a dose of 25 mg/kg per day.1 In vivo, cytogenin (30 and 100 mg/kg per day) reduces streptozotocin-induced decreases in body weight and increases in plasma glucose levels and macrophage pancreatic infiltration in a mouse model of diabetes.2 It also decreases zymosan- and LPS-induced nitric oxide production, as well as LPS-induced increases in Il-6 levels, in isolated mouse macrophages after administration at a dose of 100 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumagai, H., Masuda, T., Ohsono, M., et al. Cytogenin, a novel antitumor substance. J. Antibiot. (Tokyo) 43(11), 1505-1507 (1990).

    2. Kumagai, H., Wakazono, K., Agata, N., et al. Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice. J. Antibiot. (Tokyo) 58(3), 202-205 (2005).