An L-type calcium channel blocker
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(S)-Amlodipine

Item No. 46175

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-aminoethoxy)methyl]-4S-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid, 3-ethyl 5-methyl ester
CAS Number
103129-82-4
Synonyms
  • Levamlodipine
Molecular Formula
C20H25ClN2O5
Formula Weight
408.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CCOC(C1=C(COCCN)NC(C)=C(C(OC)=O)[C@@H]1C2=C(C=CC=C2)Cl)=O
InChi Code
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1
InChi Key
HTIQEAQVCYTUBX-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $79

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    50 mg

    $95

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    100 mg

    $142

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    250 mg

    $316

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    Product Description

    (S)-Amlodipine is an L-type calcium channel blocker and the S enantiomer of amlodipine (Item Nos. 14838 | 14886).1 It inhibits L-type calcium channel currents (IC50 = 0.62 µM) and reduces intracellular calcium levels in rat aortic smooth muscle cells. (S)-Amlodipine (1 mg/kg) induces tachycardia, decreases blood pressure, and reduces cardiac and aortic hypertrophy in spontaneously hypertensive rats.2 Formulations containing (S)-amlodipine have been used in the treatment of hypertension and coronary artery disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, R.X., Jiang, W.P., Li, X.R., et al. Effects of (S)-amlodipine and (R)-amlodipine on L-type calcium channel current of rat ventricular myocytes and cytosolic calcium of aortic smooth muscle cells. Pharmazie 63(6), 470-474 (2008).

    2. Yang, Y.L., Yu, L.T., Wu, Z.T., et al. Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats. CNS Neurosci. Ther. 18(6), 471-474 (2012).