Irisflorentin

Irisflorentin is an isoflavone that has been found in B. chinensis and has anti-inflammatory and cytoprotective activities.^1,2,3 It reduces LPS-induced increases in the levels of nitric oxide (NO), inducible NO synthase (iNOS), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages at 10, 20, and 40 µM.¹ Irisflorentin increases phagocytosis of E. coli by RAW 264.7 macrophages at 40 µM and prevents M1 polarization in mouse bone marrow-derived macrophages (BMDMs).² It also reduces the secretion of IL-6, TNF-α, and IL-10 induced by heat-inactivated methicillin-resistant S. aureus (HK-MRSA) in mouse BMDMs. Irisflorentin activates the PI3K, mTOR, and BDNF signaling pathways, increases cell viability, and reduces lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) production, and apoptosis in a PC12 cellular model of ischemic stroke using oxygen-glucose deprivation and reoxygenation.³

WARNING This product is not for human or veterinary use.

1. Gao, Y., Fang, L., Liu, F., et al. Suppressive effects of irisflorentin on LPS-induced inflammatory responses in RAW 264.7 macrophages. Exp. Biol. Med. (Maywood) 239(8), 1018-1024 (2014).

2. Xiang, T., Zou, Y., Jiang, X., et al. Irisflorentin promotes bacterial phagocytosis and inhibits inflammatory responses in macrophages during bacterial infection. Heliyon 10(1), e23225 (2023).

3. Y., Z., Lu, T., Luo, X., et al. Elucidating the mechanism of anti-ischemic stroke action of Irisflorentin: A combined approach using network pharmacology, molecular docking, and in vitro validation. Eur. J. Med. Chem. Rep. 16, 1000318 (2026).