An SGLT2 inhibitor
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Enavogliflozin

Item No. 46218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S)-1,5-anhydro-1-C-[7-chloro-6-[(4-cyclopropylphenyl)methyl]-2,3-dihydro-4-benzofuranyl]-D-glucitol
CAS Number
1415472-28-4
Synonyms
  • DWP16001
  • GCC5694A
Molecular Formula
C24H27ClO6
Formula Weight
446.9
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O[C@@H]1[C@@H](O)[C@H](C2=C3CCOC3=C(Cl)C(CC(C=C4)=CC=C4C5CC5)=C2)O[C@H](CO)[C@H]1O
InChi Code
InChI=1S/C24H27ClO6/c25-19-15(9-12-1-3-13(4-2-12)14-5-6-14)10-17(16-7-8-30-23(16)19)24-22(29)21(28)20(27)18(11-26)31-24/h1-4,10,14,18,20-22,24,26-29H,5-9,11H2/t18-,20-,21+,22-,24+/m1/s1
InChi Key
KORCWPOBTZTAFI-YVTYUBGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $99

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    5 mg

    $446

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    10 mg

    $743

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    25 mg

    $1,238

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Enavogliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 0.46 nM).1 It is selective for SGLT2 over SGLT1 (IC50 = 359 nM). Enavogliflozin increases urinary glucose excretion in rats. It also decreases blood glucose and hemoglobin A1c (HbA1c) levels in rodent models of type 1 and type 2 diabetes at 0.5 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kong, Y.K., Song, K.S., Jung, M.E., et al. Discovery of GCC5694A: A potent and selective sodium glucose co-transporter 2 inhibitor for the treatment of type 2 diabetes. Bioorg. Med. Chem. Lett. 56, 128466 (2021).