A PARP1 inhibitor
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AZD 9574

Item No. 46223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide
CAS Number
2756333-39-6
Synonyms
  • Palacaparib
Molecular Formula
C21H22F2N6O2
Formula Weight
428.4
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=NC(F)=C(N2CCN(CC2)CC3=C(F)C4=C(N=C(C)C(N4)=O)C=C3)C=C1)NC
InChi Code
InChI=1S/C21H22F2N6O2/c1-12-20(30)27-18-14(25-12)4-3-13(17(18)22)11-28-7-9-29(10-8-28)16-6-5-15(21(31)24-2)26-19(16)23/h3-6H,7-11H2,1-2H3,(H,24,31)(H,27,30)
InChi Key
WXRCLFFPZXJCLS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $275

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    10 mg

    $440

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    25 mg

    $688

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    50 mg

    $1,100

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    Cayman Chemical
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    Product Description

    AZD 9574 is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor (IC50 = 0.005 µM).1 It is selective for PARP1 over PARP2 (IC50 = >93 µM) and induces synthetic lethality in DLD-1 colorectal cancer cells lacking BRCA2 (IC50 = 0.016 µM). AZD 9574 (10-30 mg/kg) reduces tumor volume but not body weight in a BRCA2-/- DLD-1 mouse xenograft model. It has been used as an adjuvant host-directed therapy (HDT) that, when administered with isoniazid (Item No. 20378), increases survival and reduces neurological deficits in a mouse model of M. tuberculosis meningitis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johannes, J.W., Balazs, A.Y.S., Barratt, D., et al. Discovery of 6-fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}- N-methylpyridine-2-carboxamide (AZD9574): A CNS-penetrant, PARP1-selective inhibitor. J. Med. Chem. 67(24), 21717-21728 (2024).

    2. Ruiz-Gonzalez, C.E., Singh, M., Masias-Leon, Y., et al. Host-directed treatments for tuberculous meningitis utilizing a multi-platform approach across mouse and human models. Nat. Commun. 17(1), 6178 (2026).