A cereblon ligand
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Isomer(s)
462413-(2,4-Dioxo-1,3-diazinan-1-yl)-5-methylbenzoic Acid
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5-(2,4-Dioxo-1,3-diazinan-1-yl)-2-methylbenzoic Acid

Item No. 46242

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-5-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-benzoic acid
CAS Number
2703773-52-6
Molecular Formula
C12H12N2O4
Formula Weight
248.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(NC(CC1)=O)N1C(C=C2C(O)=O)=CC=C2C
InChi Code
InChI=1S/C12H12N2O4/c1-7-2-3-8(6-9(7)11(16)17)14-5-4-10(15)13-12(14)18/h2-3,6H,4-5H2,1H3,(H,16,17)(H,13,15,18)
InChi Key
ZTHGIQALEUAWMN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $79

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    5 mg

    $375

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    10 mg

    $711

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    25 mg

    $1,383

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    Product Description

    5-(2,4-Dioxo-1,3-diazinan-1-yl)-2-methylbenzoic acid is a cereblon (CRBN) ligand, building block, and derivative of phenyl dihydrouracil (PDHU).1 It has been used in the synthesis of proteolysis-targeting chimeras (PROTACs) for the degradation of bromodomain-containing protein 4 (BRD4).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shyshlyk, O., Stadnichenko, V., Diachenko, O., et al. Structure-activity relationships in a series of dihydrouracil-JQ1 conjugates: Discovery of highly potent BRD4 degraders. RSC Med. Chem. 17(7), 3231-3241 (2026).