An echinocandin antifungal
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Rezafungin (acetate)

Item No. 46263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4R,5R)-4-hydroxy-N-[[4′′-(pentyloxy)[1,1′:4′,1′′-terphenyl]-4-yl]carbonyl]-5-[2-(trimethylammonio)ethoxy]-L-ornithine]-4-[(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-allothreonine]-echinocandin B, acetate
CAS Number
1631754-41-0
Synonyms
  • CD101
Molecular Formula
C63H85N8O17 • C2H3O2
Formula Weight
1285.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
C[N+](C)(C)CCO[C@@H](NC([C@@]1([H])N(C([C@@]([H])(N2)[C@@H](C)O)=O)C[C@H](C)[C@@H]1O)=O)[C@@H](C[C@@H](C(N[C@@]([H])([C@H](O)C)C(N(C3)[C@@](C(N[C@]([C@H](O)[C@@H](O)C4=CC=C(O)C=C4)([H])C2=O)=O)([H])C[C@H]3O)=O)=O)NC(C5=CC=C(C6=CC=C(C(C=C7)=CC=C7OCCCCC)C=C6)C=C5)=O)O.O=C(C)[O-]
InChi Code
InChI=1S/C63H84N8O17.C2H4O2/c1-8-9-10-28-87-45-25-21-40(22-26-45)38-13-11-37(12-14-38)39-15-17-42(18-16-39)56(80)64-46-31-48(76)61(88-29-27-71(5,6)7)68-60(84)52-53(77)34(2)32-70(52)63(86)50(36(4)73)66-59(83)51(55(79)54(78)41-19-23-43(74)24-20-41)67-58(82)47-30-44(75)33-69(47)62(85)49(35(3)72)65-57(46)81;1-2(3)4/h11-26,34-36,44,46-55,61,72-73,75-79H,8-10,27-33H2,1-7H3,(H5-,64,65,66,67,68,74,80,81,82,83,84);1H3,(H,3,4)/t34-,35+,36+,44+,46-,47-,48+,49-,50-,51-,52-,53-,54-,55-,61+;/m0./s1
InChi Key
MXMWJAPNUIKPGF-YOFVRWEXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Rezafungin is an echinocandin antifungal and a derivative of anidulafungin (Item No. 20753).1,2 It is active against seven Candida species (MICs = ≤0.015-0.5 µg/ml) and inhibits the hyphal growth of seven Aspergillus species with minimum effective concentration (MEC) values of ≤0.015-0.3 µg/ml.2 Rezafungin (0.5-4.5 mg/kg) reduces kidney fungal burden in a mouse model of candidiasis. Formulations containing rezafungin have been used in the treatment of invasive candidiasis and candidemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garcia-Effron, G. Rezafungin-Mechanisms of action, susceptibility and resistance: Similarities and differences with the other echinocandins. J. Fungi (Basel) 6(4), 262 (2020).

    2. James, K.D., Laudeman, C.P., Malkar, N.B., et al. Structure-Activity relationships of a series of echinocandins and the discovery of CD101, a highly stable and soluble echinocandin with distinctive pharmacokinetic properties. Antimicrob Agents Chemother. 61(2), e01541-e01616 (2017).