A Cdk2/cyclin E1 and Cdk2/cyclin A2 complex inhibitor
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INX-315

Item No. 46301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-((3'-oxo-2',3'-dihydro-1'H-spiro[cyclohexane-1,4'-pyrimido[5',4':4,5]pyrrolo[2,1-c][1,2,4]triazin]-7'-yl)amino)benzenesulfonamide
CAS Number
2745060-92-6
Molecular Formula
C19H21N7O3S
Formula Weight
427.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
NS(=O)(C1=CC=C(NC2=NC(N3C45CCCCC4)=C(C=C3NNC5=O)C=N2)C=C1)=O
InChi Code
InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23)
InChi Key
KGJVKYSVVOQPDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $262

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    25 mg

    $483

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    50 mg

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    Product Description

    INX-315 is an inhibitor of the cyclin-dependent kinase 2 (Cdk2)/cyclin E1 and Cdk2/cyclin A2 complexes (IC50s = 0.6 and 2.5 nM, respectively).1 It is selective for Cdk2/cyclin E1 and Cdk2/cyclin A2 complexes over other Cdk/cyclin complexes (IC50s = 15.1-349 nM). INX-315 induces cell cycle arrest at the G1 phase in OVCAR-3 ovarian cancer and MKN1 gastric carcinoma cells. It selectively reduces the viability of ovarian cancer cells that contain an amplification for CCNE1, the gene encoding cyclin E1, (IC50s = 10-64 nM) over ovarian cancer cells that do not contain a CCNE1 amplification (IC50s = 159-3,560 nM). INX-315 (100 mg/kg) reduces tumor volume in patient-derived xenograft (PDX) mouse models of CCNE1-amplified gastric adenocarcinoma and ovarian cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dietrich, C., Trub, A., Ahn, A., et al. INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors. Cancer Discov. 14(3), 446-467 (2024).