A USP7 inhibitor
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XL177A

Item No. 46302

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-chloro-5,6,7,8-tetrahydro-N-[(4S)-5-[4-hydroxy-4-[[7-[[3-(4-methyl-1-piperazinyl)-1-oxopropyl]amino]-4-oxo-3(4H)-quinazolinyl]methyl]-1-piperidinyl]-5-oxo-4-(phenylmethyl)pentyl]-3-acridinecarboxamide
CAS Number
2417089-74-6
Molecular Formula
C48H57ClN8O5
Formula Weight
861.5
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC=C2C(N=C3CCCCC3=C2Cl)=C1)NCCC[C@H](C(N4CCC(CN5C=NC6=CC(NC(CCN7CCN(CC7)C)=O)=CC=C6C5=O)(CC4)O)=O)CC8=CC=CC=C8
InChi Code
InChI=1S/C48H57ClN8O5/c1-54-24-26-55(27-25-54)21-17-43(58)52-36-14-16-39-41(30-36)51-32-57(47(39)61)31-48(62)18-22-56(23-19-48)46(60)35(28-33-8-3-2-4-9-33)10-7-20-50-45(59)34-13-15-38-42(29-34)53-40-12-6-5-11-37(40)44(38)49/h2-4,8-9,13-16,29-30,32,35,62H,5-7,10-12,17-28,31H2,1H3,(H,50,59)(H,52,58)/t35-/m0/s1
InChi Key
UYJWYMWIVMCGQZ-DHUJRADRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $59

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    5 mg

    $207

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    10 mg

    $354

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    25 mg

    $738

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    Cayman Chemical
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    Product Description

    XL177A is an irreversible inhibitor of ubiquitin-specific protease 7 (USP7; IC50 = 0.34 nM).1 It is selective for USP7 over a panel of 41 deubiquitinating enzymes at 1 µM. XL177A decreases murine double minute 2 (MDM2) levels, increases p53 and p21 levels, and induces cell cycle arrest at the G1 phase in MCF-7 breast cancer cells. It decreases tumor volume in an NB-SD neuroblastoma mouse xenograft model at 75 mg/kg.2 XL177A also decreases mRNA expression of the genes encoding angiotensin-converting enzyme 2 (ACE2) and dipeptidyl peptidase 4 (DPP-4) in Huh7.5 cells and viral titers in BV-2 cells infected with the coronavirus mouse hepatitis virus strain 3 (MHV-3).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schauer, N.J., Liu, X., Magin, R.S., et al. Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Sci. Rep. 10(1), 5324 (2020).

    2. Cmarik, E.A., Wahi, A., Chandekar, S.S., et al. Inhibition of USP7 destabilizes the noncanonical PRC1.1 complex and induces neuroblastoma differentiation. Mol. Cancer Res. 24(7), 555-575 (2026).

    3. Huang, M.Z., Yang, Z.Y., Wang, S., et al. Antagonistic ubiquitin switching by USP7 and RNF40 orchestrates KDM6A homeostasis to license coronavirus susceptibility. Adv. Sci. (Weinh) 13(23), e18058 (2026).