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Lipid A-11

Item No. 46327

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
An ionizable cationic lipid
CAS Number
2996998-09-3
Synonyms
  • CICL1
  • L829
  • Lipid 829
Molecular Formula
C55H100N2O14
Formula Weight
1013.4
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Methyl Acetate: Soluble: ≥10 mg/ml
SMILES
O=C(N(CCOC(CC(COC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O)CCOC(CC(COC(CCCCCCCC)=O)COC(CCCCCCCC)=O)=O)OCCN(C)C
InChi Code
InChI=1S/C55H100N2O14/c1-7-11-15-19-23-27-31-49(58)68-43-47(44-69-50(59)32-28-24-20-16-12-8-2)41-53(62)65-39-36-57(55(64)67-38-35-56(5)6)37-40-66-54(63)42-48(45-70-51(60)33-29-25-21-17-13-9-3)46-71-52(61)34-30-26-22-18-14-10-4/h47-48H,7-46H2,1-6H3
InChi Key
QNRHUMWQGLBRFA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Lipid A-11 is an ionizable cationic lipid (pKa = 6.66) that has been used in the formation of targeted lipid nanoparticles (tLNPs) for the delivery of mRNA in vitro and in vivo.1,2 CD5 monoclonal antibody-conjugated tLNPs (CD5-tLNPs) containing lipid A-11 accumulate in mouse spleen to a greater extent than CD5-tLNPs containing the benchmark lipid ALC-0315 (Item No. 34337).2 CD5-tLNPs containing lipid A-11 and encapsulating mRNA encoding an anti-CD19 chimeric antigen receptor (CAR) induce CAR expression in primary human CD8+ T cells ex vivo and in cynomolgus monkeys.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Karmali, P.P., and Tanis, S. Ionizable cationic lipids and lipid nanoparticles. (2023).

    2. Hunter, T.L., Bao, Y., Zhang, Y., et al. In vivo CAR T cell generation to treat cancer and autoimmune disease. Science 388(6753), 1311-1317 (2025).