A heavy metal chelator
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MiADMSA

Item No. 46337

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
rel-2R,3S-dimercapto-butanedioic acid, 1-(3-methylbutyl) ester
CAS Number
142609-62-9
Synonyms
  • MiADMS
  • Monoisoamyl DMSA
  • Monoisoamyl meso-2,3-Dimercaptosuccinic Acid
Molecular Formula
C9H16O4S2
Formula Weight
252.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CC(C)CCOC([C@H](S)[C@H](S)C(O)=O)=O
InChi Code
InChI=1S/C9H16O4S2/c1-5(2)3-4-13-9(12)7(15)6(14)8(10)11/h5-7,14-15H,3-4H2,1-2H3,(H,10,11)/t6-,7+/m0/s1
InChi Key
RIBYSYWXWXMDSW-NKWVEPMBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $39

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    5 mg

    $137

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    10 mg

    $215

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    25 mg

    $341

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    Cayman Chemical
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    Product Description

    MiADMSA is a heavy metal chelator and an ester form of meso-2,3-dimercaptosuccinic acid (Item No. 28515).1,2 MiADMSA (100 nM) inhibits arsenic-induced increases in reactive oxygen species (ROS), colony formation, and migration and prevents arsenic-induced decreases in glutathione (GSH) levels in NBT-II rat bladder cancer cells.2 It reduces apoptosis and increases mitochondrial electron transport chain activity in rat neurons in a model of arsenic exposure.1 Oral administration of MiADMSA (50 mg/kg) decreases brain arsenic levels and increases urinary levels in arsenic-exposed rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dwivedi, N., Mehta, A., Yadav, A., et al. MiADMSA reverses impaired mitochondrial energy metabolism and neuronal apoptotic cell death after arsenic exposure in rats. Toxicol. Appl. Pharmacol. 256(3), 241-248 (2011).

    2. Sathua, K., Srivastava, S., and Flora, S.J.S. MiADMSA ameliorate arsenic induced urinary bladder carcinogenesis in vivo and in vitro. Biomed. Pharmacother. 128:110257, (2020).