A monoterpenoid with diverse biological activities
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Hericenone C

Item No. 46340

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexadecanoic acid, [4-[(2E)-3,7-dimethyl-5-oxo-2,6-octadien-1-yl]-2-formyl-3-hydroxy-5-methoxyphenyl]methyl ester
CAS Number
137592-03-1
Molecular Formula
C35H54O6
Formula Weight
570.8
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
C/C(C)=C\C(C/C(C)=C/CC1=C(C(C=O)=C(C=C1OC)COC(CCCCCCCCCCCCCCC)=O)O)=O
InChi Code
InChI=1S/C35H54O6/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-34(38)41-26-29-24-33(40-5)31(35(39)32(29)25-36)21-20-28(4)23-30(37)22-27(2)3/h20,22,24-25,39H,6-19,21,23,26H2,1-5H3/b28-20+
InChi Key
OGYBKWUOLWCQDS-VFCFBJKWSA-N
Origin
Fungus/Hericium erinaceus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Hericenone C is a polyketide synthase-derived monoterpenoid originally isolated from H. erinaceum that has diverse biological activities.1,2,3,4 It acts as an antagonist of retinoic acid receptor-related orphan receptor α (RORα), reducing RORα-mediated reporter expression in RAW 264.7 cells.3 Hericenone C reduces levels of the inflammatory marker CD11c in RAW 264.7 macrophages at 40 µM. It inhibits the accumulation of CD11c+ cells at the formalin injection site and decreases formalin-induced paw licking in mice at 10 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iacovelli, R., Poon, F., and Haslinger, K. Identification and reconstitution of the first two enzymatic steps for the biosynthesis of bioactive meroterpenoids from Hericium erinaceus (lion’s mane mushroom). Molecules 29(23), 5576 (2024).

    2. Kawagishi, H., Ando, M., Sakamoto, H., et al. Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum. Tetrahedron Lett. 32(35), 4561-4564 (1991).

    3. Li, J., Hamamura, K., Yoshida, Y., et al. Hericenone C exhibits anti-nociceptive effects through RORα-mediated suppression of TLR4 transcription. Front. Pharmacol. 17, 1703176 (2026).

    4. Li, J., Hamamura, K., Yoshida, Y., et al. Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65. Biochem. Biophys. Res. Commun. 720, 150077 (2024).