A substance P antagonist
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QWF Peptide

Item No. 46373

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-[(1,1-dimethylethoxy)carbonyl]-L-glutaminyl-1-formyl-D-tryptophyl-L-phenylalanine, phenylmethyl ester
CAS Number
126088-82-2
Synonyms
  • Boc-Gln-D-Trp(CHO)-Phe-OBzl
  • Boc-Gln-D-Trp(formyl)-Phe benzyl ester
Molecular Formula
C38H43N5O8
Formula Weight
697.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
Boc-Qw(CHO)F-OBzl
SMILES
O=C(OCC1=CC=CC=C1)[C@H](CC2=CC=CC=C2)NC([C@H](NC([C@H](CCC(N)=O)NC(OC(C)(C)C)=O)=O)CC3=CN(C=O)C4=CC=CC=C34)=O
InChi Code
InChI=1S/C38H43N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4-17,22,24,29-31H,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30+,31-/m0/s1
InChi Key
ZFZOHFAASQHWER-YPKYBTACSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

    $208

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    10 mg

    $338

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    25 mg

    $780

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    Cayman Chemical
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    Product Description

    QWF peptide is a substance P (SP) antagonist (IC50 = 0.09 µM).1 It inhibits SP-induced activation of the neurokinin-1 (NK1) receptor, human MAS-related G protein-coupled receptor family member X2 (MRGPRX2), mouse MrgprB2, and mouse MrgprA1.2 QWF peptide inhibits contractions induced by SP (Item No. 24035; IC50 = 4.7 µM) but not histamine (Item No. 33828) in guinea pig tracheal strips.1 It also inhibits mast cell degranulation induced by SP, compound 48/80 (Item No. 22173), atracurium (Item No. 17796), or ciprofloxacin (Item No. 14286) in LAD 2 cells at 100 µM.2 QWF peptide reduces SP- or compound 48/80-induced itch in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hagiwara, D., Miyake, H., Morimoto, H., et al. Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists. J. Med. Chem. 35(11), 2015-2025 (1992).

    2. Azimi, E., Reddy, V.B., Shade, K.-T.C., et al. Dual action of neurokinin-1 antagonists on Mas-related GPCRs. JCI Insight 1(16), e89362 (2016).