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Testosterone sulfate is a metabolite of testosterone.1 It is formed from enzymatic sulfonation of testosterone in the adrenal glands and testis and is present in human urine and blood. Testosterone sulfate is converted to estradiol 17-sulfate via aromatase in human placental microsomes.2 Maternal plasma levels of testosterone sulfate increase during pregnancy.1
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1. Testosterone sulphate, its biosynthesis, metabolism, measurement, functions and properties. J. Steroid Biochem. 6(8), 1287-1298 (1975).
2. Evidence of direct conversion of testosterone sulfate to estradiol 17-