A CX3CR1 antagonist
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JMS-17-2

Item No. 46412

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[3-[4-(4-chlorophenyl)-1-piperidinyl]propyl]-pyrrolo[1,2-a]quinoxalin-4(5H)-one
CAS Number
1380392-05-1
Molecular Formula
C25H26ClN3O
Formula Weight
420.0
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
ClC1=CC=C(C2CCN(CCCN(C3=C(N4C5=CC=C4)C=CC=C3)C5=O)CC2)C=C1
InChi Code
InChI=1S/C25H26ClN3O/c26-21-10-8-19(9-11-21)20-12-17-27(18-13-20)14-4-16-29-23-6-2-1-5-22(23)28-15-3-7-24(28)25(29)30/h1-3,5-11,15,20H,4,12-14,16-18H2
InChi Key
WOSMCMULWWHMIV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $143

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    50 mg

    $428

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    100 mg

    $665

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    Cayman Chemical
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    Product Description

    JMS-17-2 is a chemokine (C-X3-C motif) receptor 1 (CX3CR1) antagonist (IC50 = 0.32 nM).1 It is selective for CX3CR1 over CXCR1 and CXCR2 at 1 µM. JMS-17-2 (10 and 100 nM) inhibits the migration of MDA-MB-231 breast cancer cells induced by chemokine (C-X3-C motif) ligand 1 (CX3CL1), also known as fractalkine. It decreases tumor volume in colorectal cancer mouse xenograft models when administered alone or in combination with an anti-programmed cell death protein 1 (anti-PD-1) antibody.2 JMS-17-2 reverses depressive-like behaviors and microglia-mediated excessive synapse pruning in Il15ra-/- mice.3 It decreases mechanical allodynia and spinal microglia M1 polarization in a mouse model of endometriosis.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, F., Zhang, Y., Jernigan, D.L., et al. Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res. 14(6), 518-527 (2016).

    2. Zi, R., Zhao, X., Liu, L., et al. Metabolic-immune suppression mediated by the SIRT1-CX3CL1 axis induces functional enhancement of regulatory T cells in colorectal carcinoma. Adv. Sci. (Weinh) 12(17), e2404734 (2025).

    3. Tang, Y., Huang, Y., Pan, J., et al. IL-15 receptor alpha deficiency triggers depressive-like behaviors via enhanced microglial synapse pruning. Mol. Psychiatry 31(9), 5048-5061 (2026).

    4. Wu, Q., Yang, F., Yang, R., et al. CX3CR1/P2X4R signaling-mediated spinal microglial M1 polarization contributes to chronic pelvic pain in endometriosis. Int. Immunopharmacol. 175, 116471 (2026).