An inhibitor of mitochondrial complex I and autophagy
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Aumitin

Item No. 46418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[4-[[4-methyl-6-(phenylamino)-2-pyrimidinyl]amino]phenyl]-benzamide
CAS Number
946293-78-3
Molecular Formula
C24H20ClN5O
Formula Weight
429.9
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=C(C=CC=C1)Cl)NC2=CC=C(NC3=NC(C)=CC(NC4=CC=CC=C4)=N3)C=C2
InChi Code
InChI=1S/C24H20ClN5O/c1-16-15-22(27-17-7-3-2-4-8-17)30-24(26-16)29-19-13-11-18(12-14-19)28-23(31)20-9-5-6-10-21(20)25/h2-15H,1H3,(H,28,31)(H2,26,27,29,30)
InChi Key
VJNNQBDSUIVCKB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $66

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    5 mg

    $297

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    10 mg

    $462

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    25 mg

    $825

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    Product Description

    Aumitin is an inhibitor of mitochondrial complex I, also known as NADH dehydrogenase, and autophagy.1 It is selective for mitochondrial complex I over mitochondrial complex II, -III, and -IV at 3 µM and a panel of 417 kinases at 1 µM. However, aumitin does inhibit PI4Kβ and PI3KC2γ. Aumitin inhibits mitochondrial respiration in HeLa cervical and MCF-7 breast cancer cells (IC50s = 0.11 and 0.44 µM, respectively) and starvation- or rapamycin-induced autophagy in MCF-7 cells (IC50s = 0.124 and 0.244 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robke, L., Futamura, Y., Konstantinidis, G., et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem. Sci. 9(11), 3014-3022 (2018).