A CRF1 antagonist
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Verucerfont

Item No. 46451

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-N-[(1S)-1-(3-methyl-1,2,4-oxadiazol-5-yl)propyl]-pyrazolo[1,5-a]pyrimidin-7-amine
CAS Number
885220-61-1
Synonyms
  • GSK561679
  • NBI-77860
Molecular Formula
C22H26N6O2
Formula Weight
406.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CC1=NN(C(N[C@H](C2=NC(C)=NO2)CC)=CC(C)=N3)C3=C1C4=C(C=C(C=C4)OC)C
InChi Code
InChI=1S/C22H26N6O2/c1-7-18(22-24-15(5)27-30-22)25-19-11-13(3)23-21-20(14(4)26-28(19)21)17-9-8-16(29-6)10-12(17)2/h8-11,18,25H,7H2,1-6H3/t18-/m0/s1
InChi Key
VKHVAUKFLBBZFJ-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $233

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    10 mg

    $441

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    Product Description

    Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist (Ki = 6.3 nM).1 It inhibits sauvagine-induced release of adrenocorticotropic hormone (ACTH) in rat anterior pituitary cells (IC50 = 100 nM). Verucerfont (10 mg/kg) reduces plasma ACTH levels in adrenalectomized rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tellew, J.E., Lanier, M., Moorjani, M., et al. Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg. Med. Chem. Lett. 20(24), 7259-7264 (2010).

    2. Schwandt, M.L., Cortes, C.R., Kwako, L.E., et al. The CRF1 antagonist verucerfont in anxious alcohol-dependent women: Translation of neuroendocrine, but not of anti-craving effects. Neuropsychopharmacology 41(12), 2818-28929 (2016).