MY-1076

MY-1076 is an inhibitor of tubulin polymerization and an inducer of Yes-associated transcriptional regulator (YAP) degradation.¹ It inhibits tubulin polymerization, but not nuclear division, in MGC803 and SGC-7901 gastric cancer cells at 10-30 nM and induces degradation of YAP in MGC803 cells in a concentration-dependent manner. MY-1076 inhibits the proliferation of MGC803 and SGC-7901 gastric, HCT116 colon, and KYSE-450 esophageal cancer cells (IC₅₀s = 0.019, 0.017, 0.02, and 0.044 µM, respectively). It also induces cell cycle arrest at the G₂/M phase and apoptosis in MGC803 and SGC-7901 cells. MY-1076 (5 µg/kg per day) reduces pulmonary metastasis induced by MEOHP, a metabolite of the environmental contaminant DEHP, in a T24 bladder cancer mouse xenograft model, with a greater reduction when administered in combination with ICG-001 (Item No. 16257).²

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1. Fu, X.J., Huang, J., Li, N., et al. Design, synthesis and biological evaluation of N-benzylaryl cinnamide derivatives as tubulin polymerization inhibitors capable of promoting YAP degradation with potent anti-gastric cancer activities. Eur. J. Med. Chem. 262, 115883 (2023).

2. Wang, Y., Ni, H., Dong, S., et al. Environmental dose MEOHP promotes bladder cancer progress through hybrid EMT mechanism: Based on the adverse outcome pathway. Environ. Sci. Technol. 60(8), 5979-5990 (2026).