A PPARγ agonist
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DS-6930

Item No. 46506

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[6-[(3,5-dimethyl-2-pyridinyl)oxy]-1-methyl-1H-benzimidazol-2-yl]methoxy]-benzoic acid
CAS Number
1242328-82-0
Molecular Formula
C23H21N3O4
Formula Weight
403.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC(OCC2=NC3=C(C=C(C=C3)OC4=NC=C(C)C=C4C)N2C)=CC=C1)O
InChi Code
InChI=1S/C23H21N3O4/c1-14-9-15(2)22(24-12-14)30-18-7-8-19-20(11-18)26(3)21(25-19)13-29-17-6-4-5-16(10-17)23(27)28/h4-12H,13H2,1-3H3,(H,27,28)
InChi Key
GEGLFSVXCSGSOB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $113

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    10 mg

    $200

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    25 mg

    $438

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    DS-6930 is an agonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It is selective for PPARγ over PPARα in reporter assays (EC50s = 41 and >10,000 nM, respectively). DS-6930 (3 mg/kg) reduces plasma glucose levels and body weight gain in Zucker diabetic fatty (ZDF) rats. It also inhibits viral replication in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50 = 0.36 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shinozuka, T., Tsukada, T., Fujii, K., et al. Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization. Bioorg. Med. Chem. 26(18), 5099-5117 (2018).

    2. Riva, L., Yuan, S., Yin, X., et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. Nature 586(7827), 113-119 (2020).