A modified nucleoside
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2'-O-Methylpseudouridine

Item No. 46554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-O-methyl-β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione
CAS Number
2140-68-3
Molecular Formula
C10H14N2O6
Formula Weight
258.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](OC)[C@@H]1O
InChi Code
InChI=1S/C10H14N2O6/c1-17-8-6(14)5(3-13)18-7(8)4-2-11-10(16)12-9(4)15/h2,5-8,13-14H,3H2,1H3,(H2,11,12,15,16)/t5-,6-,7+,8-/m1/s1
InChi Key
WGNUTGFETAXDTJ-OOJXKGFFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

    $158

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    10 mg

    $280

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    25 mg

    $525

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    Product Description

    2'-O-Methylpseudouridine is a modified nucleoside that has been found in prokaryotic tRNA and human rRNA.1,2 It has been used in the synthesis of oligonucleotides.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Edmonds, C.G., Crain, P.F., Gupta, R., et al. Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria). J. Bacteriol. 173(10), 3138-3148 (1991).

    2. Taoka, M., Nobe, Y., Yamaki, Y., et al. Landscape of the complete RNA chemical modifications in the human 80S ribosome. Nucleic Acids Res. 46(18), 9289-9298 (2018).

    3. Ross, B.S., Vasquez, G., Manalili, S., et al. Synthesis and incorporation of 2′-O-methyl-pseudouridine into oligonucleotides. Nucleosides Nucleotides 16 (7-9), 1547-1549 (1997).