A DGAT-1 inhibitor
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AZD 3988

Item No. 46565

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[4-[[[5-[(3,4-difluorophenyl)amino]-1,3,4-oxadiazol-2-yl]carbonyl]amino]phenyl]-cyclohexaneacetic acid
CAS Number
892489-52-0
Molecular Formula
C23H22F2N4O4
Formula Weight
456.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=NN=C(NC2=CC(F)=C(C=C2)F)O1)NC3=CC=C([C@@H]4CC[C@H](CC4)CC(O)=O)C=C3
InChi Code
InChI=1S/C23H22F2N4O4/c24-18-10-9-17(12-19(18)25)27-23-29-28-22(33-23)21(32)26-16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-20(30)31/h5-10,12-14H,1-4,11H2,(H,26,32)(H,27,29)(H,30,31)/t13-,14-
InChi Key
NGEBYTLALFOQKI-HDJSIYSDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $254

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    AZD 3988 is an inhibitor of diacylglycerol acyltransferase 1 (DGAT-1; IC50 = 0.6 nM for the human enzyme).1 It is selective for DGAT-1 over DGAT-2 at 10 µM. AZD 3988 inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 0.5 nM) and oleic acid-induced lipid droplet accumulation in human duodenal organoids at 100 nM.1,2 It decreases plasma triglyceride levels in an oral lipid tolerance test in fasted rats. AZD 3988 (20 mg/kg, p.o.) reduces body weight in diet-induced obese (DIO) mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCoull, W., Addie, M.S., Birch, A.M., et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg. Med. Chem. Lett. 22(12), 3873-3878 (2012).

    2. van Rijn, J.M., Ardy, R.C., Kuloğlu, Z., et al. Intestinal failure and aberrant lipid metabolism in patients with DGAT1 deficiency. Gastroenterology 155(1), 130-143.e115 (2018).