A TAZ modulator
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TM-25659

Item No. 46618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2′(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]3H-imidazo[4,5-b]pyridine
CAS Number
260553-97-7
Molecular Formula
C30H28N8
Formula Weight
500.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CC1=NC2=C(C=C1C3=CC=CN=C3)N=C(N2CC4=CC=C(C5=C(C=CC=C5)C6=NN=NN6)C=C4)CCCC
InChi Code
InChI=1S/C30H28N8/c1-3-4-11-28-33-27-17-26(23-8-7-16-31-18-23)20(2)32-30(27)38(28)19-21-12-14-22(15-13-21)24-9-5-6-10-25(24)29-34-36-37-35-29/h5-10,12-18H,3-4,11,19H2,1-2H3,(H,34,35,36,37)
InChi Key
KCOQNLYGMQJUJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $89

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    10 mg

    $142

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    50 mg

    $445

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    100 mg

    $712

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    TM-25659 is a modulator of transcriptional coactivator with PDZ-binding motif (TAZ).1 It increases nuclear localization of TAZ in C3H/10T1/2 cells and reduces differentiation of 3T3-L1 mouse preadipocytes mediated by peroxisome proliferator-activated receptor γ (PPARγ) at 100 µM. It also increases C3H/10T1/2 osteoblast differentiation at 50 µM. TM-25659 (50 mg/kg) reduces weight gain in a mouse model of high-fat diet-induced obesity. In addition, it reduces weight gain and partially restores bone mineral density in a rat model of ovariectomy-induced bone loss.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jang, E.J., Jeong, H., Kang, J.O., et al. TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ. Br. J. Pharmacol. 165(5), 1584-1594 (2012).