A 5-HT1B and 5-HT1D antagonist
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GR125743

Item No. 46671

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-3-methyl-4-(4-pyridinyl)-benzamide
CAS Number
148547-33-5
Molecular Formula
C25H28N4O2
Formula Weight
416.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(C1=CC(C)=C(C2=CC=NC=C2)C=C1)NC3=CC=C(C(N4CCN(CC4)C)=C3)OC
InChi Code
InChI=1S/C25H28N4O2/c1-18-16-20(4-6-22(18)19-8-10-26-11-9-19)25(30)27-21-5-7-24(31-3)23(17-21)29-14-12-28(2)13-15-29/h4-11,16-17H,12-15H2,1-3H3,(H,27,30)
InChi Key
GNOXPYACARZYMW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $143

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    25 mg

    $285

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    50 mg

    $428

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    Product Description

    GR125743 is an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D.1 It binds to the 5-HT1B and 5-HT1D receptors in HeLa cells expressing the human receptors (Kds = 1.02 and 6.2 nM, respectively). Radiolabeled forms of GR125743 have been used to evaluate other potential ligands of the 5-HT1B and 5-HT1D receptors.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Doménech, T., Beleta, J., and Palacios, J.M. Characterization of human serotonin 1D and 1B receptors using [3H]-GR-125743, a novel radiolabelled serotonin 5HT1D/1B receptor antagonist. Naunyn Schmiedebergs Arch. Pharmacol. 356(3), 328-334 (1997).