A ferroptosis inhibitor
Related Products
Alternative(s)
17730Liproxstatin-1
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Liproxstatin-1 (hydrochloride)

Item No. 46710

Product Insert (PDF)
Technical Information
Formal Name
N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2′(1′H)-quinoxalin]-3′-amine, monohydrochloride
CAS Number
2250025-95-5
Molecular Formula
C19H21ClN4 • HCl
Formula Weight
377.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/mlMethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
ClC1=CC=CC(CNC2=NC3=C(NC24CCNCC4)C=CC=C3)=C1.Cl
InChi Code
InChI=1S/C19H21ClN4.ClH/c20-15-5-3-4-14(12-15)13-22-18-19(8-10-21-11-9-19)24-17-7-2-1-6-16(17)23-18;/h1-7,12,21,24H,8-11,13H2,(H,22,23);1H
InChi Key
HEHOHTKMIOBTKC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $69

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    10 mg

    $131

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    25 mg

    $276

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    50 mg

    $380

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    Product Description

    Liproxstatin-1 is a ferroptosis inhibitor.1 It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockout of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by the ferroptosis-inducing agents L-buthionine sulphoximine (BSO), erastin (Item No. 17754), and (1S,3R)-RSL3 (Item No. 19288) in a concentration-dependent manner in MEFs, but does not inhibit necroptosis, apoptosis, or necrosis. It inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in primary human renal proximal tubule epithelial cells. Liproxstatin-1 (10 mg/kg) increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice and reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury. It is also an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Friedmann Angeli, J.P., Schneider, M., Proneth, B., et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell. Biol. 16(12), 1180-1191 (2014).

    2. Zilka, O., Shah, R., Li, B., et al. On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death. ACS Cent. Sci. 3(3), 232-243 (2017).