An MMP-9 inhibitor
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MMP-9-IN-6

Item No. 46740

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(2,5-diphenyl-3-furanyl)-4-methoxy-1H-indole
CAS Number
2241964-36-1
Synonyms
  • Matrix Metalloproteinase 9-IN-6
  • Matrix Metalloproteinase 9 Inhibitor 6
  • MMP 9 Inhibitor 6
Molecular Formula
C25H19NO2
Formula Weight
365.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
COC1=CC=CC2=C1C(C3=C(C4=CC=CC=C4)OC(C5=CC=CC=C5)=C3)=CN2
InChi Code
InChI=1S/C25H19NO2/c1-27-22-14-8-13-21-24(22)20(16-26-21)19-15-23(17-9-4-2-5-10-17)28-25(19)18-11-6-3-7-12-18/h2-16,26H,1H3
InChi Key
YEIMVHHFMFOHPQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $45

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    5 mg

    $169

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    10 mg

    $248

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    25 mg

    $394

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    Product Description

    MMP-9-IN-6 is an inhibitor of matrix metalloproteinase-9 (MMP-9; IC50 = 50 µM).1 It inhibits gastric ulceration induced by indomethacin (Item No. 70270) by 95% in mice at 50 mg/kg. MMP-9-IN-6 reduces indomethacin-induced increases in stomach myeloperoxidase (MPO) activity, protein carbonylation, and lipid peroxidation in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rudra, D.S., Chatterjee, S., Pal, U., et al. Newly synthesized 3-indolyl furanoid inhibits matrix metalloproteinase-9 activity and prevents nonsteroidal anti-inflammatory drug-induced gastric ulceration. J. Med. Chem. 66(13), 8917-8928 (2023).