A convenient tool for studying MDR protein modulators
Features
  • A non-radioactive assay for multi-drug resistance associated protein (MRP) function in living cells
  • Employ calcein AM, a substrate for multi-drug resistance proteins, including P-gp and MRP
  • Cyclosporin A and verapamil are included as positive controls of MDR inhibition
  • Assess by flow cytometry, fluorescence microscopy, or plate reader
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Multidrug Resistance Assay Kit (Calcein AM)

Item No. 600370

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • MDR
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1,000 tests

    $290

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    Product Description

    Cayman's Multidrug Resistance Assay Kit provides a convenient tool for studying the modulation of cellular multidrug resistance (MDR) machinery. The kit employs calcein AM, a cell-permeable nonfluorescent dye, which is cleaved intracellularly to yield the impermeant fluorescent molecule, calcein. This calcein is rapidly excluded from cells expressing the MDR proteins P-gp or MRP, and so functions as a probe for the detection of chemical compounds inhibiting MDR proteins. Propidium iodide is provided as a stain for marking dead or damaged cells. Cyclosporin A, a competitive inhibitor of MDR proteins, and verapamil, a noncompetitive inhibitor, are included as controls.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.