An inositol phosphate
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D-myo-Inositol-1,3,4-triphosphate (sodium salt)

Item No. 60972

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-myo-inositol-1,3,4-tris(dihydrogen phosphate), trisodium salt
Synonyms
  • Ins(1,3,4)-P3 (sodium salt)
  • 1,3,4-IP3 (sodium salt)
Molecular Formula
C6H12O15P3 • 3Na
Formula Weight
486.0
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: >50 mg/ml (from D-myo-Inositol
SMILES
O[C@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3+,4?,5?,6?;;;/m1.../s1
InChi Key
ZVCVTWVBDIPWPZ-WWKACLBASA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    D-myo-Inositol-1,3,4-triphosphate (Ins(1,3,4)-P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels.1 The levels of Ins(1,3,4)-P3 are in turn regulated by the levels of cytosolic free calcium.2 The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.3

    WARNING This product is not for human or veterinary use.