Active, pure human recombinant protein
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PPARγ FL (human, recombinant from E. coli)

Item No. 61700

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Peroxisome Proliferator-activated Receptor γ Full Length
Purity
≥80% estimated by SDS-PAGE
Source
Human recombinant N-terminal His-tagged protein expressed in E. coli
MW
~60 kDa
Formulation (Request formulation change)
A solution in 20 mM Tris HCl, pH 8.0, containing 250 mM KCl, 20% glycerol, 5 mM DTT, and 0.5 mM EDTA
UniProt Accession №
P37231
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    25 µg

    $334

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    50 µg

    $636

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor family of ligand activated transcription factors that heterodimerizes with retinoic acid-like receptors to regulate gene expression and differentiation.1 The PPAR family of nuclear hormone receptors consists of three subtypes encoded by separate genes: PPARα, PPARδ (also referred to as hNUC1, PPARβ, or FAAR), and PPARγ. Among them PPARγ is the most widely studied and has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancer.2 PPARγ is primarily expressed in adipose tissue and to a lesser extent in the colon, immune system, and the retina.3 PPARγ FL (human, recombinant from E. coli) purity was determined using gel electrophoresis followed by coomassie staining.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kersten, S., Desvergne, B., and Wahli, W. Roles of PPARs in health and disease. Nature 405(6785), 421-424 (2000).

    2. Vidal-Puig, A., Jimenez-Linan, M., Lowell, B.B., et al. Regulation of PPAR γ gene expression by nutrition and obesity in rodents. J. Clin. Invest. 97(11), 2553-2561 (1996).

    3. Clark, R.B. The role of PPARs in inflammation and immunity. J. Leukoc. Biol. 71(3), 388-400 (2002).