An abundant naturally-occurring ceramide
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Labeled Version(s)
22790C24:1 Ceramide-d7 (d18:1-d7/24:1(15Z))
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Product Categories

Product Type

Biochemicals
Lipids
Sphingolipids

Research Area

Lipid Biochemistry
Sphingolipids

C24:1 Ceramide (d18:1/24:1(15Z))

Item No. 62530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-15Z-tetracosenamide
CAS Number
54164-50-0
Synonyms
  • Ceramide (d18:1/24:1(15Z))
  • Cer(d18:1/24:1(15Z))
  • Nervonic Ceramide
  • N-Nervonoyl-D-erythro-Sphingosine
Molecular Formula
C42H81NO3
Formula Weight
648.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: Slightly solubleEthanol: 1 mg/mlEthanol:PBS (pH 7.2)(1:1): 0.5 mg/mlPBS pH 7.2: Slightly soluble
SMILES
OC[C@H](NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC
InChi Code
InChI=1S/C42H81NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,35,37,40-41,44-45H,3-16,19-34,36,38-39H2,1-2H3,(H,43,46)/b18-17-,37-35+/t40-,41+/m0/s1
InChi Key
VJSBNBBOSZJDKB-KPEYJIHVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $219

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    25 mg

    $462

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    Product Description

    C24:1 Ceramide (d18:1/24:1(15Z)) is one of the most abundant naturally occurring ceramides.1,2,3 Ceramides mediate many diverse biological activities, as has been demonstrated in studies utilizing cell-permeable ceramide analogs. A few of the processes regulated by ceramides include apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gu, Q., Kerwin, J.L., Watts, J.D., et al. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal. Biochem. 244(2), 347-356 (1997).

    2. Clayton, R.B., Cooper, J.M., Curstedt, T., et al. Stimulation of erythroblast maturation in vitro by sphingolipids. J. Lipid Res. 15(6), 557-562 (1974).

    3. Krivit, W., and Hammarström, S. Identification and quantitation of free ceramides in human platelets. J. Lipid Res. 13(4), 525-530 (1972).

    4. Testi, R. Sphingomyelin breakdown and cell fate. Trends Biochem. Sci. 21(12), 468-471 (1996).

    5. Augé, N., Andrieu, N., Nègre-Salvayre, A., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996).

    6. Gudz, T.I., Tserng, K.Y., and Hoppel, C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997).