A potent CD36 ligand
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KOdiA-PC

Item No. 62945

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine
CAS Number
439904-33-3
Molecular Formula
C32H58NO11P
Formula Weight
663.8
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: .5 mg/mlDMSO: .5 mg/mlEthanol: 30 mg/mlPBS (pH7.2): 5 mg/ml
SMILES
O=P([O-])(OCC[N+](C)(C)C)OC[C@H](OC(CCCC(/C=C/C(O)=O)=O)=O)COC(CCCCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C32H58NO11P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-31(37)41-26-29(27-43-45(39,40)42-25-24-33(2,3)4)44-32(38)21-18-19-28(34)22-23-30(35)36/h22-23,29H,5-21,24-27H2,1-4H3,(H-,35,36,39,40)/b23-22+/t29-/m1/s1
InChi Key
PEZXEQJZQAVYCZ-NLMPBQEBSA-N
Side Chain Carbon Sum
24:1
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $87

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    1 mg

    $165

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    5 mg

    $653

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    10 mg

    $869

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    Product Description

    1-(Palmitoyl)-2-(5-keto-6-octene-dioyl) phosphatidylcholine, or KOdiA-PC, is one of the most potent CD36 ligands among the oxLDL species.1 KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle, and may be one of the more important structural determinants of oxLDL.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Podrez, E.A., Poliakov, E., Shen, Z., et al. Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36. The Journal of Biological Chemisty 277(41), 38503-38516 (2002).

    Product Citations

    Souza, A.C., Bocharov, A.B., Baranova, I.N., et al. Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation. Kidney Int. 89(4), 809-822 (2016).