A competitive ELISA for screening cGAS inhibitors
Features
  • Screen for inhibitors of human cGAS
  • Directly measure 2'3'-cGAMP as an indicator of cGAS activity
  • Run 36 samples at one dilution or 18 samples at two dilutions
  • Rapid assay; get results in 3 hours
  • Plate-based colorimetric measurement (450 nm)
  • View our video guide for more information: cGAS Inhibitor Screening Assay Kit
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cGAS Inhibitor Screening Assay Kit

Item No. 701930

Kit Booklet (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • C6orf150
  • 2'3'-cGAMP Synthase
  • Cyclic GMP-AMP Synthase
Limit of Detection
5.0 pM
Assay Range
4.6-10,000 pM
Sensitivity
48.4 pM
License
This product was developed in conjunction with BIOLOG Life Science Institute.
Origin
Animal/Bovine, Animal/Rabbit
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    96 solid wells

    $679

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    96 strip wells

    $679

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    Cayman Chemical
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    Product Description

    Cayman’s cGAS Inhibitor Screening Assay Kit provides a robust and easy-to-use platform for identifying novel inhibitors of human cGAS, which is a cytosolic dsDNA sensor that detects microbial pathogens. The assay directly measures 2’3’-cGAMP produced by cGAS in the presence of DNA, ATP, and GTP. The cyclic dinucleotide product of that reaction is quantified via ELISA using a 2’3’-cGAMP-specific antiserum. The cGAS inhibitor CU-76 is included as a positive control.

    The ELISA portion of Cayman’s cGAS Inhibitor Screening Assay Kit is a competitive assay with a range of 4.57-10,000 pM, a midpoint of approximately 300 pM (50% B/B0), and a sensitivity (80% B/B0) of approximately 50 pM.

    Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.

    WARNING This product is not for human or veterinary use.