A non-competitive inhibitor of Δ5-desaturase
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Sesamin

Item No. 70310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1S-(1α,3aα,4α,6aα)]-5,5'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole
CAS Number
607-80-7
Molecular Formula
C20H18O6
Formula Weight
354.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS (1:10): 50 µg/mlDMSO: 12 mg/mlEthanol: 0.5 mg/ml
λmax
235, 286 nm
SMILES
C1OC2=CC=[C@H](C=C2O1)[C@H]1OC[C@@H]2[C@H](OC[C@H]12)c1ccc2OCOc2c1
InChi Code
InChI=1S/C20H18O6/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1
InChi Key
PEYUIKBAABKQKQ-AFHBHXEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Sesamin is a non-competitive inhibitor of Δ5-desaturase. It inhibits the conversion of DGLA to arachidonic acid with a Ki value of 155 µM in rat liver microsomes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shimizu, S., Akimoto, K., Sugano, M., et al. Studies on desaturase inhibitors of polyunsaturated fatty acid biosynthesis. Essential Fatty Acids and Eicosanoids 37-41 (1992).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).