An antagonist of cysteinyl-leukotriene receptors
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REV 5901

Item No. 70600

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-pentyl-3-(2-quinolinylmethoxy)-benzenemethanol
CAS Number
101910-24-1
Molecular Formula
C22H25NO2
Formula Weight
335.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
acidic PBS: <50 µg/mlbasic PBS: <50 µg/mlDMF: >36 mg/mlDMSO: >19 mg/mlEthanol: >70 mg/mlPBS pH 7.2: <50 µg/ml
SMILES
CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1
InChi Code
InChI=1S/C22H25NO2/c1-2-3-4-12-22(24)18-9-7-10-20(15-18)25-16-19-14-13-17-8-5-6-11-21(17)23-19/h5-11,13-15,22,24H,2-4,12,16H2,1H3
InChi Key
JRLOEMCOOZSCQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    50 mg

    $268

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    100 mg

    $469

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    Product Description

    REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 µM for guinea pig lung membranes.1 It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Van Inwegen, R.G., Khandwala, A., Gordon, R., et al. REV 5901: An orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. J. Pharmacol. Exp. Ther. 241, 117-124 (1987).

    2. Musser, J.H., Charkraborty, U.R., Sciortino, S., et al. Substituted arylmethyl phenyl ethers. 1. A novel series of 5-lipoxygenase inhibitors and leukotriene antagonists. J. Med. Chem. 30, 96-104 (1987).