An antiangiogenic agent
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Isomer(s)
29325Hydroxysulochrin
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Asterric Acid

Item No. 70630

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-carboxy-3-hydroxy-5-methylphenoxy)-5-hydroxy-3-methoxy-benzoic acid, 1-methyl ester
CAS Number
577-64-0
Synonyms
  • Dimethylosoic Acid
  • RES-1214-1
  • TAN 1415A
Molecular Formula
C17H16O8
Formula Weight
348.3
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
λmax
214, 252, 315 nm
SMILES
CC1=CC(O)=C(C(O)=O)C(OC2=C(OC)C=C(O)C=C2C(OC)=O)=C1
InChi Code
InChI=1S/C17H16O8/c1-8-4-11(19)14(16(20)21)12(5-8)25-15-10(17(22)24-3)6-9(18)7-13(15)23-2/h4-7,18-19H,1-3H3,(H,20,21)
InChi Key
XOKVHFNTYHPEHN-UHFFFAOYSA-N
Origin
Fungus/Aspergillus terreus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Asterric acid is an antibiotic fungal metabolite that completely inhibits the binding of the potent vasoconstrictor endothelin (ET)-1 to the ETA receptor in A10 cells at 0.1 μM.1 Asterric acid derivatives have also been shown to inhibit VEGF-induced tube formation of human umbilical vein endothelial cells at 3-10 μM, which suggests its usefulness as an antiangiogenic agent.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohashi, H., Akiyama, H., Nishikori, K., et al. Asterric acid, a new endothelin binding inhibitor. J. Antibiot. (Tokyo) 45, 1684-1685 (1992).

    2. Lee, H.J., Lee, J.H., Hwang, B.Y., et al. Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. J. Antibiot. (Tokyo) 55(6), 552-556 (2002).