An NSAID and COX inhibitor
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Ketorolac (tromethamine salt)

Item No. 70690

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, tris(hydroxymethyl)aminomethane salt
CAS Number
74103-07-4
Synonyms
  • Toradol
Molecular Formula
C15H12NO3 • C4H12NO3
Formula Weight
376.4
Purity
≥99%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 7 mg/mlPBS pH 7.2: 26 mg/ml
λmax
243, 317 nm
SMILES
O=C(C1=CC=C2N1CCC2C([O-])=O)C3=CC=CC=C3.[NH3+]C(CO)(CO)CO
InChi Code
InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2
InChi Key
BWHLPLXXIDYSNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).1 It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac (Item No. 11348) and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Shaffer, A., Portanova, J., et al. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. J. Pharmacol. Exp. Ther. 283(3), 1069-1075 (1997).