A BLT1 receptor antagonist
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U-75302

Item No. 70705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(6-(3R-hydroxy-1E,5Z-undecadien-1-yl)-2-pyridinyl)-1,5S-hexanediol
CAS Number
119477-85-9
Molecular Formula
C22H35NO3
Formula Weight
361.5
Purity
≥95%
Formulation
A 500 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 7.1 mg/mlDMSO: 10 mg/mlEthanol: 50 mg/mlPBS 7.2: 80 µg/ml
SMILES
OCCCC[C@H](O)CC1=NC(/C=C/[C@H](O)C/C=C\CCCCC)=CC=C1
InChi Code
InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m1/s1
InChi Key
JNBOAUIJLDEICX-LJCAKPRGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $96

    Add

    100 µg

    $183

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    500 µg

    $764

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    1 mg

    $1,050

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    Product Description

    U-75302 is an LTB4 receptor antagonist with a Ki of 159 nM on guinea pig lung membranes.1,2 This activity is specific for the BLT1 receptor; U-75302 does not antagonize the binding of [3H]-LTB4 to the human BLT2 receptor.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Falcone, R.C., and Aharony, D. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J. Pharmacol. Exp. Ther. 255, 565-571 (1990).

    2. Lin, A.H., Morris, J., Wishka, D.G., et al. Novel molecules that antagonize leukotriene B4 binding to neutrophils. Ann. N.Y. Acad. Sci. 524, 196-200 (1988).

    3. Wang, S., Gustafson, E., Pang, L., et al. A novel hepatointestinal leukotriene B4 receptor. The Journal of Biological Chemisty 275(52), 40686-40694 (2000).

    Product Citations

    Tsuda, S., Shinohara, M., Oshita, T., et al. Novel mechanism of regulation of the 5-lipoxygenase/leukotriene B4 pathway by high-density lipoprotein in macrophages. Sci. Rep. 7(1), 12989 (2017).