Selective, potent LTD4 receptor antagonist
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LY171883

Item No. 70710

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]-ethanone
CAS Number
88107-10-2
Molecular Formula
C16H22N4O3
Formula Weight
318.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlSodium Bicarbonate (0.5M): 15 mg/ml
λmax
218, 284 nm
SMILES
CCCc1c(OCCCCc2nnn[nH]2)ccc(C(=O)C)c1O
InChi Code
InChI=1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
InChi Key
MWYHLEQJTQJHSS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $84

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    50 mg

    $344

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    100 mg

    $600

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    Product Description

    LY171883 is a selective, potent, orally active antagonist of the leukotriene D4 receptor.1 Dissociation constants (KB) for LY171883 on guinea pig ileum and parenchyma are 0.07 and 0.34 µM, respectively.1 LY171883 is an inhibitor of phosphodiesterase obtained from human polymorphonuclear leukocytes (IC50 of 22.6 µM) and various guinea pig tissues (IC50s range from 6.9-209 µM).1 At a concentration of 50-100 µM, LY171883 binds to the PPARγ nuclear receptor, inducing adipogenesis in cultured NIH3T3 fibroblasts.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fleisch, J.H., Rinkema, L.E., Haisch, K.D., et al. LY171883, 1-[2-hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone, an orally active leukotriene D4 antagonist. J. Pharmacol. Exp. Ther. 233(1), 148-157 (1985).

    2. Sala, A., Rossoni, G., Buccellati, C., et al. Formation of sulphidopeptide-leukotrienes by cell-cell interaction causes coronary vasoconstriction in isolated, cell-perfused heart of rabbit. Br. J. Pharmacol. 110(3), 1206-1212 (1993).

    3. Tontonoz, P., Hu, E., and Spiegelman, B.M. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 79(7), 1147-1156 (1994).