A BLT2 receptor antagonist
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LY255283

Item No. 70715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone
CAS Number
117690-79-6
Molecular Formula
C19H28N4O3
Formula Weight
360.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (pH 7.2) (1:1): .1 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
213, 232, 276, 326 nm
SMILES
CCc1c(OCCCCCC(C)(C)c2nnn[nH]2)cc(O)cc1C(=O)C
InChi Code
InChI=1S/C19H28N4O3/c1-5-15-16(13(2)24)11-14(25)12-17(15)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)
InChi Key
VSDBVKWYFGKZPY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM.1 LY255283 exhibits IC50 values of ~950 nM and >10 µM at human recombinant BLT2 and BLT1 receptors, respectively.2 LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 µM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Silbaugh, S.A., Stengel, P.W., Cockerham, S.L., et al. Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur. J. Pharmacol. 223, 57-64 (1992).

    2. Yokomizo, T., Kato, K., Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. The Journal of Biological Chemisty 276(15), 12454-12459 (2001).

    3. Richards, I.M., Sun, F.F., Taylor, B.M., et al. Contribution of leukotriene B4 to airway inflammation and the effect of antagonists. Ann. N. Y. Acad. Sci. 629, 274-287 (1991).